| First Author | Struillou L | Year | 1995 |
| Journal | Antimicrob Agents Chemother | Volume | 39 |
| Issue | 4 | Pages | 878-81 |
| PubMed ID | 7785988 | Mgi Jnum | J:25132 |
| Mgi Id | MGI:72860 | Doi | 10.1128/aac.39.4.878 |
| Citation | Struillou L, et al. (1995) Activities of roxithromycin against Mycobacterium avium infections in human macrophages and C57BL/6 mice. Antimicrob Agents Chemother 39(4):878-81 |
| abstractText | The activity of roxithromycin against three clinical isolates of Mycobacterium avium was compared with that of clarithromycin both in a model of infection of human monocyte-derived macrophages and in a model of established infection of C57BL/6 mice. In the cell culture model, roxithromycin and clarithromycin were bactericidal for strains MO-1 and N-92159 and bacteriostatic for strain N-93043. For the three strains, the differences between the intracellular activities of roxithromycin and clarithromycin were not singificant after 7 days of treatment. Mice were infected with the MO-1 strain. Drugs were given by gavage at a dosage of 200 mg/kg of body weight 6 days per week for 16 weeks starting 5 weeks after infection. At the end of treatment, clarithromycin was more effective than roxithromycin in lungs; roxithromycin was as effective as clarithromycin in spleens. Thus, the activity of roxithromycin was comparable to that of clarithromycin both in vitro and in vivo. |
