| Primary Identifier | MGI:99841 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 15566 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; detection of mechanical stimulus involved in sensory perception of pain; and modulation of chemical synaptic transmission. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in axon terminus; neuronal cell body; and synaptic vesicle. Predicted to be active in dendrite; postsynaptic membrane; and presynaptic membrane. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to human HTR7 (5-hydroxytryptamine receptor 7). PHENOTYPE: Mice homozygous for a knock-out allele display lower electrically- and chemically-induced seizure thresholds. Mice homozygous for a different knock-out allele show enhanced coordination and higher thermal nociceptive thresholds. Other nullizygous mutantsfail to exhibit agonist-induced hypothermia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
