| First Author | Volf D | Year | 1978 |
| Journal | J Exp Med | Volume | 147 |
| Issue | 3 | Pages | 940-5 |
| PubMed ID | 305463 | Mgi Jnum | J:5955 |
| Mgi Id | MGI:54432 | Doi | 10.1084/jem.147.3.940 |
| Citation | Volf D, et al. (1978) Induction of partial chimerism in nonirradiated B-lymphocyte-deficient CBA/N mice. J Exp Med 147(3):940-5 |
| abstractText | Nonirradiated B-lymphocyte-deficient CBA/N mice given T6T6 chromosome-marked normal CBA/CaHN spleen cells became lymphoid chimeras exhibiting donor-type mitoses. Normal CBA/CaHN recipients did not exhibit significant numbers of donor-type mitoses. The lymphoid cell chimerism in the CBA/N host appeared in spleen, lymph nodes, and Peyer's patches, but not in marrow or thymus. Stimulation of CBA/N-recipient spleen cells in vitro suggested that the chimerism involved donor T6T6 cells which were responsive to the B-lymphocyte mitogen, lipopolysaccharide, but not to the T-lymphocyte mitogen, phytohemagglutinin. These data indicate that stable, long-term chimerism of a specific class of lymphocytes is possible in nonirradiated, B-lymphocyte-deficient CBA/N mice. |
