| First Author | Gardner RT | Year | 2015 |
| Journal | Nat Commun | Volume | 6 |
| Pages | 6235 | PubMed ID | 25639594 |
| Mgi Jnum | J:221367 | Mgi Id | MGI:5638978 |
| Doi | 10.1038/ncomms7235 | Citation | Gardner RT, et al. (2015) Targeting protein tyrosine phosphatase sigma after myocardial infarction restores cardiac sympathetic innervation and prevents arrhythmias. Nat Commun 6:6235 |
| abstractText | Millions of people suffer a myocardial infarction (MI) every year, and those who survive have increased risk of arrhythmias and sudden cardiac death. Recent clinical studies have identified sympathetic denervation as a predictor of increased arrhythmia susceptibility. Chondroitin sulfate proteoglycans present in the cardiac scar after MI prevent sympathetic reinnervation by binding the neuronal protein tyrosine phosphatase receptor sigma (PTPsigma). Here we show that the absence of PTPsigma, or pharmacologic modulation of PTPsigma by the novel intracellular sigma peptide (ISP) beginning 3 days after injury, restores sympathetic innervation to the scar and markedly reduces arrhythmia susceptibility. Using optical mapping we observe increased dispersion of action potential duration, supersensitivity to beta-adrenergic receptor stimulation and Ca(2+) mishandling following MI. Sympathetic reinnervation prevents these changes and renders hearts remarkably resistant to induced arrhythmias. |
