| Primary Identifier | MGI:1354171 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 50498 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables interleukin-27 receptor binding activity. Involved in T cell proliferation. Predicted to be located in extracellular space and membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including decidua; extraembryonic component; sensory organ; and skeleton. Orthologous to human EBI3 (Epstein-Barr virus induced 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit significantly reduced numbers of invariant natural killer (NK) T cells, show impaired Th2 responses, are resistant to the induction of oxazolone-induced colitis, and display impaired early Th1 immunity against Leishmania parasitic infections. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
