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Protein Coding Gene : Racgap1 Rac GTPase-activating protein 1

Primary Identifier  MGI:1349423 Organism  mouse, laboratory
Chromosome  15 NCBI Gene Number  26934
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Predicted to enable several functions, including GTPase activator activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and tubulin binding activity. Involved in neuroblast proliferation and regulation of embryonic development. Predicted to be located in cytoplasmic side of plasma membrane; mitotic spindle; and nucleoplasm. Predicted to be part of centralspindlin complex. Predicted to be active in several cellular components, including cleavage furrow; midbody; and spindle midzone. Is expressed in several structures, including blastocyst; central nervous system; early embryo; neural retina; and nose. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia. Orthologous to human RACGAP1 (Rac GTPase activating protein 1).
PHENOTYPE: Embryos homozygous for a gene-trapped allele exhibit pre-implantation lethality associated with the formation of multinucleated blastomeres and failure to complete cytokinesis. [provided by MGI curators]
  • synonyms:
  • Rac GTPase-activating protein 1,
  • MGI:2145986,
  • expressed sequence AI227039,
  • AI327394,
  • Racgap1,
  • Band25,
  • mKIAA1478,
  • GTPase,
  • gtl11,
  • AI227039,
  • MgcRacGAP,
  • MGI:2145962,
  • expressed sequence AI327394

Features --> Cross References

Genome

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

3 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

23 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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0 Driver For