| First Author | Gao X | Year | 2002 |
| Journal | Cell Immunol | Volume | 219 |
| Issue | 2 | Pages | 119-30 |
| PubMed ID | 12576030 | Mgi Jnum | J:115536 |
| Mgi Id | MGI:3691904 | Doi | 10.1016/s0008-8749(02)00597-x |
| Citation | Gao X, et al. (2002) Role of cell cycle regulator p19ARF in regulating T cell responses. Cell Immunol 219(2):119-30 |
| abstractText | Although it is well established that the processes of cellular proliferation and apoptosis are linked, the role of cell cycle regulators in T cell responses in vivo is not well understood. In recent years, tumor suppressor molecule p19(ARF) has emerged as a key cell cycle regulator important in cellular apoptosis against strong mitogenic stimuli. In this study, we compared the antigen-specific T cell responses between wild type (+/+) and p19(ARF)-deficient (p19-/-) mice following an acute infection with lymphocytic choriomeningitis virus (LCMV). p19-/- mice mounted a potent CD8 T cell response and the magnitude of expansion of LCMV-specific CD8 T cells was comparable to that of +/+ mice. Further, the clonal downsizing of the expanded virus-specific CD8 T cells and establishment of long-term T cell memory were minimally affected by p19(ARF) deficiency. Therefore, p19(ARF) function is not essential to regulate T cell responses following an acute viral infection. |
