| First Author | Hayashiji N | Year | 2015 |
| Journal | Nat Commun | Volume | 6 |
| Pages | 6745 | PubMed ID | 25865621 |
| Mgi Jnum | J:222723 | Mgi Id | MGI:5645428 |
| Doi | 10.1038/ncomms7745 | Citation | Hayashiji N, et al. (2015) G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy. Nat Commun 6:6745 |
| abstractText | Duchenne muscular dystrophy (DMD) is a chronic and life-threatening disease that is initially supported by muscle regeneration but eventually shows satellite cell exhaustion and muscular dysfunction. The life-long maintenance of skeletal muscle homoeostasis requires the satellite stem cell pool to be preserved. Asymmetric cell division plays a pivotal role in the maintenance of the satellite cell pool. Here we show that granulocyte colony-stimulating factor receptor (G-CSFR) is asymmetrically expressed in activated satellite cells. G-CSF positively affects the satellite cell population during multiple stages of differentiation in ex vivo cultured fibres. G-CSF could be important in developing an effective therapy for DMD based on its potential to modulate the supply of multiple stages of regenerated myocytes. This study shows that the G-CSF-G-CSFR axis is fundamentally important for long-term muscle regeneration, functional maintenance and lifespan extension in mouse models of DMD with varying severities. |
