| First Author | Sumoza-Toledo A | Year | 2006 |
| Journal | J Immunol | Volume | 176 |
| Issue | 10 | Pages | 5779-87 |
| PubMed ID | 16670283 | Mgi Jnum | J:131685 |
| Mgi Id | MGI:3774207 | Doi | 10.4049/jimmunol.176.10.5779 |
| Citation | Sumoza-Toledo A, et al. (2006) Regulatory T cells inhibit protein kinase C theta recruitment to the immune synapse of naive T cells with the same antigen specificity. J Immunol 176(10):5779-87 |
| abstractText | The precise mechanisms by which regulatory T cells operate, particularly their effect on signaling pathways leading to T cell activation, are poorly understood. In this study we have used regulatory T (Treg) cells of known Ag specificity, generated in vivo, to address their effects on early activation events occurring in naive T cells of the same Ag specificity. We found that the Treg cells need to be present at the moment of priming to suppress activation and proliferation of the naive T cell. Furthermore, the Treg cells significantly inhibit the recruitment of protein kinase Ctheta (PKCtheta) to the immune synapse of the naive T cell as long as both T cells are of the same Ag specificity and are contacting the same APC. Finally, naturally occurring CD4(+)25(+) T cells seem to have the same effect on PKCtheta recruitment in CD25(-) T cells of the same Ag specificity. These results suggest that although additional mechanisms of regulation are likely to exist, inhibition of PKCtheta recruitment in the effector T cell may be a common regulatory pathway leading to the absence of NF-kappaB activation and contributing to the block of IL-2 secretion characteristic of immune suppression. |
