| First Author | Perry LL | Year | 1991 |
| Journal | J Virol | Volume | 65 |
| Issue | 7 | Pages | 3429-34 |
| PubMed ID | 1674967 | Mgi Jnum | J:24692 |
| Mgi Id | MGI:72425 | Doi | 10.1128/jvi.65.7.3429-3434.1991 |
| Citation | Perry LL, et al. (1991) Role of CD4+ and CD8+ T cells in murine resistance to street rabies virus. J Virol 65(7):3429-34 |
| abstractText | Mice of the SJL/J and BALB/cByJ inbred strains are naturally resistant to street rabies virus (SRV) injected via the intraperitoneal route. To determine the cellular mechanism of resistance, monoclonal antibodies specific for CD4+ or CD8+ subsets of T cells were used to deplete the respective cell population in SRV-infected animals. Elimination of CD4+ T-helper cells abrogated the production of immunoglobulin G (IgG) neutralizing antibodies in response to rabies virus infection and reversed the resistant status of SJL/J and BALB/cByJ mice. In contrast, in vivo depletion of CD8+ cytotoxic T cells had no measurable effect on host resistance to SRV. These results indicate that serum neutralizing antibodies of the IgG class are a primary immunological mechanism of defense against rabies virus infection in this murine model of disease. CD8+ cytotoxic T lymphocytes, which have been shown to transfer protection in other rabies virus systems, appear to have no role in protecting mice against intraperitoneally injected SRV. |
