Primary Identifier | IPR027465 | Type | Homologous_superfamily |
Short Name | TIMP_C |
description | The tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of the matrix metalloproteinases (MMPs). TIMPs have two domains, a larger N-terminal domain that carries the MMP-inhibitory activity, and a smaller C-domain that mediates other interactions, notably non-inhibitory interactions of TIMP-1 with pro-MMP-9 and of TIMP-2 with pro-MMP-2 [, , ].This superfamily represents the C-terminal domain. |