| First Author | Woodland DL | Year | 1991 |
| Journal | J Exp Med | Volume | 174 |
| Issue | 5 | Pages | 1255-8 |
| PubMed ID | 1658187 | Mgi Jnum | J:2275 |
| Mgi Id | MGI:50799 | Doi | 10.1084/jem.174.5.1255 |
| Citation | Woodland DL, et al. (1991) Endogenous superantigen expression is controlled by mouse mammary tumor proviral loci. J Exp Med 174(5):1255-8 |
| abstractText | Superantigens are defined by their ability to stimulate T cells based predominantly on their V beta expression and ability to delete T cells in the thymus when expressed endogenously. We show here that the expression of one endogenous superantigen, Etc-1, is controlled by the expression of the open reading frame region of the 3' long terminal repeat of the mouse mammary tumor proviral gene, Mtv-9. We show that Mtv-8 controls a superantigen with similar specificity, and that both Mtv-8 and Mtv-9 stimulate some V beta 17+ T cells. A third provirus, Mtv-6, controls a superantigen with specificity for V beta 3. Data presented raise the possibility that endogenous superantigens may compete for class II molecules in a single B cell. |
