Primary Identifier | MGI:1861099 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 224826 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables histone ubiquitin ligase activity. Involved in several processes, including heterochromatin formation; male gamete generation; and reciprocal meiotic recombination. Acts upstream of or within male meiosis I and ubiquitin-dependent protein catabolic process. Part of chromatin and ubiquitin ligase complex. Is expressed in several structures, including alimentary system; endocrine gland; eye; genitourinary system; and trachea. Orthologous to human UBR2 (ubiquitin protein ligase E3 component n-recognin 2). PHENOTYPE: On a mixed genetic background, female homozygotes for a targeted null mutation exhibit embryonic lethality, while males are viable, but sterile due to postnatal testicular degeneration. On an inbred background, both genders die in utero. [provided by MGI curators] |