| Primary Identifier | IPR030492 | Type | Conserved_site |
| Short Name | RHD_CS |
| description | Members of the Rel family share a highly conserved 300 amino acids domain termed Rel homology domain (RHD) which is located towards the amino terminus. The unique C terminus is thought to be involved in gene activation and cytoplasmic anchoring functions.For several proteins it has been demonstrated []that the Rel homology domain includes:a DNA-binding domain, which binds to the consensus DNA sequence motif5'-GGGRNNYYCC-3' (except for dorsal, which recognises the related motif5'-GRGAAAANCC-3');a dimerisation domain, which is located in the C-terminal part of theRHD;a PKA phosphorylation site (except in RelB);a nuclear localization signal (NLS), which consists of a stretch of fouror five basic residues.This entry represents a conserved site located at theN terminus of the RHD. It includes a conserved cysteine that seems tobe essential for DNA-binding in p50 []. |
