| First Author | Peng C | Year | 2012 |
| Journal | Biochem Biophys Res Commun | Volume | 423 |
| Issue | 4 | Pages | 715-20 |
| PubMed ID | 22699122 | Mgi Jnum | J:185970 |
| Mgi Id | MGI:5430687 | Doi | 10.1016/j.bbrc.2012.06.021 |
| Citation | Peng C, et al. (2012) Vps18 deficiency inhibits dendritogenesis in Purkinje cells by blocking the lysosomal degradation of Lysyl Oxidase. Biochem Biophys Res Commun 423(4):715-20 |
| abstractText | Dendrite development occupies a central position in the formation of nervous system. However, whether lysosomal degradative function is required for dendritogenesis of neurons remains unknown. We have recently demonstrated the critical role of Vps18 in the lysosomal degradation pathway in mice. Here, we report that Vps18 deficiency severely blocks the dendrite development of Pukinje cells but not cerebral cortical neurons. Furthermore, we also demonstrate that the lysyl oxidase (Lox) protein is degraded through lysosome and accumulated in the Vps18 deficient cerebellum but not in cerebral cortices. Our results suggest that lysosome regulates dendritogenesis of Purkinje cells though degrading Lox. |
