Primary Identifier | MGI:2141866 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 101489 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable G-protein alpha-subunit binding activity; GTPase activator activity; and guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including basement membrane organization; gastrulation; and visual learning. Located in membrane. Is expressed in several structures, including alimentary system; extraembryonic component; female reproductive system; nervous system; and sensory organ. Orthologous to human RIC8A (RIC8 guanine nucleotide exchange factor A). PHENOTYPE: Homozygous mutation of this gene results in lethality during gastrulation. Heterozygotes exhibit impaired spatial learning and increased anxiety. [provided by MGI curators] |