| First Author | Bouchon A | Year | 2000 |
| Journal | J Immunol | Volume | 164 |
| Issue | 10 | Pages | 4991-5 |
| PubMed ID | 10799849 | Mgi Jnum | J:64954 |
| Mgi Id | MGI:1891507 | Doi | 10.4049/jimmunol.164.10.4991 |
| Citation | Bouchon A, et al. (2000) Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol 164(10):4991-5 |
| abstractText | We have identified new activating receptors of the Ig superfamily expressed on human myeloid cells, called TREM (triggering receptor expressed on myeloid cells). TREM-1 is selectively expressed on blood neutrophils and a subset of monocytes and is up-regulated by bacterial LPS. Engagement of TREM-1 triggers secretion of IL-8, monocyte chemotactic protein-1, and TNF-alpha and induces neutrophil degranulation. Intracellularly, TREM-1 induces Ca2+ mobilization and tyrosine phosphorylation of extracellular signal-related kinase 1 (ERK1), ERK2 and phospholipase C-gamma. To mediate activation, TREM-1 associates with the transmembrane adapter molecule DAP12. Thus, TREM-1 mediates activation of neutrophil and monocytes, and may have a predominant role in inflammatory responses. |
