| First Author | Nakayama T | Year | 1998 |
| Journal | FEBS Lett | Volume | 428 |
| Issue | 1-2 | Pages | 80-4 |
| PubMed ID | 9645480 | Mgi Jnum | J:49331 |
| Mgi Id | MGI:1328821 | Doi | 10.1016/s0014-5793(98)00497-9 |
| Citation | Nakayama T, et al. (1998) N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression. FEBS Lett 428(1-2):80-4 |
| abstractText | Neuronal activity is often associated with changes in gene expression. By a two-dimensional cDNA-display system, restriction landmark cDNA scanning, we identified a novel gene whose expression in the hippocampus was up-regulated by kainate stimulation. The mRNA expression was detected only in brain and up-regulated by the stimulation evoking CA3-CA1 long-term potentiation. The encoded protein contains two copies of C2-domain, known as the Ca2+-binding domain of PKC-gamma, and shows 49% identity with human copine I. We designated this protein N-copine (neuronal-copine). N-copine may have a role in synaptic plasticity. |
