| First Author | Hansen TH | Year | 1977 |
| Journal | J Exp Med | Volume | 145 |
| Issue | 6 | Pages | 1550-8 |
| PubMed ID | 68094 | Mgi Jnum | J:5815 |
| Mgi Id | MGI:54292 | Doi | 10.1084/jem.145.6.1550 |
| Citation | Hansen TH, et al. (1977) Mutation in a new H-2-associated histocompatibility gene closely linked to H-2D. J Exp Med 145(6):1550-8 |
| abstractText | Sequential precipitations of soluble BALB/c antigen with antisera detecting private and public H-2 specificities indicated three distinct classes of molecules of 45,000 mol wt. However, only two of these classes of molecules were detectable in antigen from the loss mutant, BALB/c-H-2db. The class of molecules, detectable in the wild-type strain but missing in the mutant, does not bear private specificities but does react with an antiserum detecting H-2 public specificities. Absorption in mutant mice of the antiserum to public specificities, left antibodies specific for the antigen detectable in BALB/c but not BALB/c-H-2db. Genetic mapping studies using this specific antiserum indicated that the antigenic loss of this mutant is in a gene which maps in or close to the H-2D region, separable from the H-2K, S, G, Qa-2, and Tla regions. |
