| First Author | McEvilly RJ | Year | 2002 |
| Journal | Science | Volume | 295 |
| Issue | 5559 | Pages | 1528-32 |
| PubMed ID | 11859196 | Mgi Jnum | J:74989 |
| Mgi Id | MGI:2159524 | Doi | 10.1126/science.1067132 |
| Citation | McEvilly RJ, et al. (2002) Transcriptional regulation of cortical neuron migration by POU domain factors. Science 295(5559):1528-32 |
| abstractText | The identification of pathways mediated by the kinase Cdk5 and the ligand reelin has provided a conceptual framework for exploring the molecular mechanisms underlying proper lamination of the developing mammalian cerebral cortex. In this report, we identify a component of the regulation of Cdk5-mediated cortical lamination by genetic analysis of the roles of the class III POU domain transcription factors, Brn-1 and Brn-2, expressed during the development of the forebrain and coexpressed in most layer II-V cortical neurons. Brn-1 and Brn-2 appear to critically control the initiation of radial migration, redundantly regulating the cell-autonomous expression of the p35 and p39 regulatory subunits of Cdk5 in migrating cortical neurons, with Brn-1(-/-)/Brn-2(-/-) mice exhibiting cortical inversion. |
