| Primary Identifier | MGI:2155278 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 140742 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Involved in cellular response to amino acid stimulus; negative regulation of TORC1 signaling; and negative regulation of cell growth. Acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in cytoplasm; fibrillar center; and nucleoplasm. Predicted to be part of GATOR2 complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human SESN1 (sestrin 1). PHENOTYPE: Mice homozygous for a kncok-out allele exhibit enhanced responsiveness to an influenza vaccine in aged mice. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
