| First Author | Moussaoui S | Year | 1996 |
| Journal | FEBS Lett | Volume | 383 |
| Issue | 3 | Pages | 219-22 |
| PubMed ID | 8925899 | Mgi Jnum | J:32242 |
| Mgi Id | MGI:79724 | Doi | 10.1016/0014-5793(96)00250-5 |
| Citation | Moussaoui S, et al. (1996) Immunohistochemical analysis of presenilin-1 expression in the mouse brain. FEBS Lett 383(3):219-22 |
| abstractText | At least 22 different mutations associated with early-onset familial Alzheimer's disease (AD) in various kindreds have been reported to occur in a recently identified gene on chromosome 14, presenilin 1 (PS-1) (Sherrington et al. (1995) Nature 375, 754-760 [1] and reviewed by Van Broeckhoven (1995) Nat. Genet. 11, 230-231 [2]). In order to study the localization of PS-1 in the brain, we raised a polyclonal antiserum specific to a fragment of the predicted protein sequence of PS-1. PS-1 immunostaining was found intracellularly, in the perikaria of discrete cells, mostly neurons, appearing as thick granules, resembling large-size vesicles. These granules were located in the periphery of cell bodies and extended into dendrites and neurites. PS-1 expression was found to be broadly distributed throughout the mouse brain, not only in structures involved in AD pathology, but also in structures unaltered by this disease. |
