| First Author | Ishige K | Year | 1999 |
| Journal | Neurosci Lett | Volume | 262 |
| Issue | 1 | Pages | 53-6 |
| PubMed ID | 10076871 | Mgi Jnum | J:56009 |
| Mgi Id | MGI:1339874 | Doi | 10.1016/s0304-3940(99)00033-6 |
| Citation | Ishige K, et al. (1999) Characterization of absence seizure-dependent cyclic AMP responsive element-and activator protein 1 DNA-binding activities in lethargic (lh/lh) mice. Neurosci Lett 262(1):53-6 |
| abstractText | The characterized nuclear cyclic AMP responsive element (CRE)- and activator protein 1 (AP-1) DNA-binding activities in various brain regions of lethargic (lh/lh) mice, a genetic model of absence seizures. Gel-shift assays showed that nuclear CRE- and AP-1 DNA-binding activities in the thalamus and cerebral cortex, but not in other regions such as the hippocampus and cerebellum of lethargic mice were significantly higher than those of non-epileptic control mice. Furthermore, CRE- and AP-1 DNA-binding activities in lethargic mice, but not control mice, were inhibited by the specific GABA(B) receptor antagonist CGP 46831, at a dose which suppressed seizure behavior and spike and wave discharges. These results suggest that enhanced nuclear CRE- and AP-1 DNA-binding activities in the thalamocortical region are related to generation and/or propagation of absence seizures in lethargic mice. |
