| First Author | Ahmad W | Year | 1998 |
| Journal | Science | Volume | 279 |
| Issue | 5351 | Pages | 720-4 |
| PubMed ID | 9445480 | Mgi Jnum | J:45689 |
| Mgi Id | MGI:1195844 | Doi | 10.1126/science.279.5351.720 |
| Citation | Ahmad W, et al. (1998) Alopecia universalis associated with a mutation in the human hairless gene. Science 279(5351):720-4 |
| abstractText | There are several forms of hereditary human hair loss, known collectively as alopecias, the molecular bases of which are entirely unknown. A kindred with a rare, recessively inherited type of alopecia universalis was used to search for a locus by homozygosity mapping, and linkage was established in a 6-centimorgan interval on chromosome 8p12 (the logarithm of the odds favoring linkage score was 6.19). The human homolog of a murine gene, hairless, was localized in this interval by radiation hybrid mapping, and a missense mutation was found in affected individuals. Human hairless encodes a putative single zinc finger transcription factor protein with restricted expression in the brain and skin. |
