Primary Identifier | MGI:1920706 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 73456 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables protein binding activity involved in heterotypic cell-cell adhesion; protein homodimerization activity; and signaling receptor binding activity. Involved in fusion of sperm to egg plasma membrane involved in single fertilization; heterotypic cell-cell adhesion; and sperm-egg recognition. Located in acrosomal membrane; endoplasmic reticulum membrane; and plasma membrane. Part of protein complex involved in cell-cell adhesion. Orthologous to human IZUMO1 (izumo sperm-oocyte fusion 1). PHENOTYPE: Homozygous null male mice are infertile due to inability of sperm to fuse with the egg. [provided by MGI curators] |