First Author | Kasper M | Year | 2013 |
Journal | Cancer Cell | Volume | 23 |
Issue | 1 | Pages | 3-5 |
PubMed ID | 23328478 | Mgi Jnum | J:194345 |
Mgi Id | MGI:5473461 | Doi | 10.1016/j.ccr.2012.12.011 |
Citation | Kasper M, et al. (2013) Smoothing out drug resistance. Cancer Cell 23(1):3-5 |
abstractText | Smoothened inhibitors have emerged as successful treatment alternatives for Hedgehog pathway-dependent tumors, but they are linked with the appearance of drug resistance. In this issue of Cancer Cell, Kim and colleagues overcome such resistance by combining approved drugs itraconazole and arsenic trioxide, thus opening a path toward new treatment options. |