| First Author | Liu Y | Year | 1993 |
| Journal | Biochim Biophys Acta | Volume | 1216 |
| Issue | 2 | Pages | 299-303 |
| PubMed ID | 8241272 | Mgi Jnum | J:15708 |
| Mgi Id | MGI:63823 | Doi | 10.1016/0167-4781(93)90159-b |
| Citation | Liu Y, et al. (1993) Molecular cloning and characterization of cDNA encoding mouse hepatocyte growth factor. Biochim Biophys Acta 1216(2):299-303 |
| abstractText | A cDNA encoding mouse hepatocyte growth factor (HGF) has been cloned and completely sequenced by use of reverse transcriptase-polymerase chain reaction (RT-PCR) and subsequent cloning. Sequence analysis reveals that mouse HGF, similar to its human and rat counterparts, consists of 728 amino acids, and both the alpha- and beta-chains are encoded in a single open reading frame. Strong homology exists in the primary structure of HGF among the three species of mouse, rat and human (more than 90%), especially in Kringle 1 of the alpha chain which is assumed to be an essential domain for binding of HGF to its receptor, c-MET, a proto-oncogene product. Our results suggest the existence of evolutionary pressure to conserve the distinct structure, and presumably the biological functions, of HGF. |
