Primary Identifier | MGI:2158744 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Casp1 |
Transmission | Germline | Strain of Origin | 129S2/SvPas |
Is Recombinase | false | Is Wild Type | false |
description | The ES cells used to generate this allele contain the linked Casp4del truncated allele that fails to produce a functional Casp4. Phenotypes associated with this allele may be affected by the presence of the Caspdel allele. J:193522 |
molecularNote | A genomic fragment containing part of exon 6 and exon 7 was replaced with a neomycin selection cassette. RT-PCR analysis on samples derived from homozygous mice demonstrated that no detectable transcript was produced from this allele. |