| First Author | Hemmers S | Year | 2015 |
| Journal | Cell Rep | Volume | 11 |
| Issue | 9 | Pages | 1339-49 |
| PubMed ID | 26004187 | Mgi Jnum | J:228594 |
| Mgi Id | MGI:5708000 | Doi | 10.1016/j.celrep.2015.04.058 |
| Citation | Hemmers S, et al. (2015) The Cell-Intrinsic Circadian Clock Is Dispensable for Lymphocyte Differentiation and Function. Cell Rep 11(9):1339-49 |
| abstractText | Circadian rhythms regulate many aspects of physiology, ranging from sleep-wake cycles and metabolic parameters to susceptibility to infection. The molecular clock, with transcription factor BMAL1 at its core, controls both central and cell-intrinsic circadian rhythms. Using a circadian reporter, we observed dynamic regulation of clock activity in lymphocytes. However, its disruption upon conditional Bmal1 ablation did not alter T- or B-cell differentiation or function. Although the magnitude of interleukin 2 (IL-2) production was affected by the time of bacterial infection, it was independent of cell-intrinsic expression of BMAL1. The circadian gating of the IL-2 response was preserved in Bmal1-deficient T cells, despite a slight reduction in cytokine production in a competitive setting. Our results suggest that, contrary to the prevailing view, the adaptive immune response is not affected by the cell-intrinsic clock but is likely influenced by cell-extrinsic circadian cues operating across multiple cell types. |
