| Primary Identifier | IPR034538 | Type | Domain |
| Short Name | ACF_RRM1 |
| description | This entry represents the RNA recognition motif 1 (RRM1) of ACF. ACF (APOBEC-1-stimulating protein, also known as ASP) is an RNA-binding subunit of a core complex that interacts with apoB mRNA to facilitate C to U RNA editing [, ]. It may also act as an apoB mRNA recognition factor and chaperone, and play a key role in cell growth and differentiation. ACF shuttles between the cytoplasm and nucleus []. ACF contains three RNA recognition motifs (RRMs), which display high affinity for an 11 nucleotide AU-rich mooring sequence 3' of the edited cytidine in apoB mRNA. All three RRMs may be required for complementation of editing activity in living cells. RRM2/3 are implicated in ACF interaction with APOBEC-1 []. |
