| First Author | Genc B | Year | 2001 |
| Journal | Brain Res Dev Brain Res | Volume | 132 |
| Issue | 1 | Pages | 107-11 |
| PubMed ID | 11744114 | Mgi Jnum | J:73670 |
| Mgi Id | MGI:2156258 | Doi | 10.1016/s0165-3806(01)00297-8 |
| Citation | Genc B, et al. (2001) Whisker-related neural patterns develop normally despite severe whisker defects in Msx2 knockout mice. Brain Res Dev Brain Res 132(1):107-11 |
| abstractText | In mice, whiskers on the snout form a highly specialized tactile organ with exquisitely patterned neural representations in the brain. Targeted deletion of the Msx2 gene leads to severe craniofacial defects, and stubby, curly whiskers. We examined the whisker pad histology, innervation, and whisker-related pattern formation along the trigeminal pathway in Msx2 -/- mice. Although the whiskers are severely deformed, whisker follicle structure, pattern and density of innervation, as well as central neural patterns in the brainstem, thalamus, and cortex appeared normal. We conclude that whisker-related neural patterns can form in the absence of normal whiskers, as long as whisker follicle innervation is intact. |
