| First Author | Zisimopoulou P | Year | 1998 |
| Journal | Mol Gen Genet | Volume | 260 |
| Issue | 2-3 | Pages | 295-9 |
| PubMed ID | 9862484 | Mgi Jnum | J:51511 |
| Mgi Id | MGI:1316843 | Doi | 10.1007/s004380050898 |
| Citation | Zisimopoulou P, et al. (1998) Mouse homolog of the yeast origin recognition complex subunit ORC1 and chromosomal localization of the cognate mouse gene Orc1. Mol Gen Genet 260(2-3):295-9 |
| abstractText | ORC1 encodes a subunit of the eukaryotic origin recognition complex in yeast, which has been shown to play a crucial role in chromosomal DNA replication and transcriptional silencing. We have identified a mouse protein closely related to Saccharomyces cerevisiae ORC1 as well as to the human, Xenopus and Drosophila homologs. MmORC1 has putative cyclin- dependent phosphorylation sites and a nucleotide triphosphate-binding motif. We have mapped the gene locus of the murine Orc1 gene to chromosome 4, band D. Conservation of structures among members of the ORC1-related proteins suggests that these proteins play a key role in the intiation of DNA replication in all eukaryotes. |
