| Primary Identifier | MGI:1312921 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 12368 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables cysteine-type endopeptidase activity involved in apoptotic process. Predicted to be involved in several processes, including acute inflammatory response to non-antigenic stimulus; cellular response to staurosporine; and positive regulation of programmed cell death. Predicted to act upstream of or within regulation of apoptotic process. Predicted to be located in several cellular components, including axon; neuronal cell body; and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and vibrissa. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CASP6 (caspase 6). PHENOTYPE: Mice homozygous for a knock-out allele exhibit failure to induce increased lysis of fluorogenic substrate VEID-AMC in staurosporine treated of lenses. Mice homozygous for a different knock-out allele exhibit resistance to excitotoxicity and axonal degeneration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
