| First Author | Chen L | Year | 1993 |
| Journal | Dev Genet | Volume | 14 |
| Issue | 5 | Pages | 339-46 |
| PubMed ID | 8293576 | Mgi Jnum | J:38724 |
| Mgi Id | MGI:86106 | Doi | 10.1002/dvg.1020140503 |
| Citation | Chen L, et al. (1993) A murine CDC25/ras-GRF-related protein implicated in Ras regulation. Dev Genet 14(5):339-46 |
| abstractText | A partial cDNA encoding a novel putative p2, ras guanine nucleotide release-inducing factor (GRF), GRF2, was amplified from murine embryonic stem cells. The presumptive catalytic region of GRF2 is related to the yeast Ras GRF encoded by CDC25. GRF2 is 80% identical to murine CDC25Mm/ras-GRF, but is more similar to yeast CDC25 than to other ras GRFs related to the Drosophila son of sevenless gene product. A 9-kb GRF2 messenger RNA was highly expressed in brain, but GRF2-specific antibodies recognized apparent GRF2 proteins in various mouse tissues in addition to brain. Thus GRF2 represents a novel widely-expressed protein that is highly related to CDC25Mm/ras-GRF, at least in its catalytic domain. Both GRF2 and CDC25Mm/ras-GRF are expressed in murine embryonic stem cells, suggesting that different Ras activators may regulate ras-dependent proliferation and differentiation in early mouse development. |
