| First Author | O'Tuathaigh CM | Year | 2006 |
| Journal | Neuroreport | Volume | 17 |
| Issue | 1 | Pages | 79-83 |
| PubMed ID | 16361955 | Mgi Jnum | J:104927 |
| Mgi Id | MGI:3613134 | Doi | 10.1097/01.wnr.0000192738.31029.0a |
| Citation | O'Tuathaigh CM, et al. (2006) Sexually dimorphic changes in the exploratory and habituation profiles of heterozygous neuregulin-1 knockout mice. Neuroreport 17(1):79-83 |
| abstractText | The neuregulin-1 gene is widely expressed in the central nervous system and is associated with increased risk for schizophrenia. Using an ethologically based approach, the phenotype of neuregulin-1 heterozygous knockout mice was examined by revealing the individual elements of behaviour in the murine repertoire over the prolonged course of interaction with the environment. During initial exploration, neuregulin-1 mutants displayed a phenotype characterized by increases in locomotion and rearing free, with sex-specific alterations in sifting and grooming. Over subsequent habituation, certain initial effects endured while new phenotypic effects emerged, some of which were again sex-specific. These studies elaborate a pleiotropic role of neuregulin-1 in development, plasticity and function, including sexual dimorphism, by defining the elemental, temporal and sex-specific characteristics of the neuregulin-1 mutant ethogram. |
