| First Author | Cosker KE | Year | 2016 |
| Journal | Nat Neurosci | Volume | 19 |
| Issue | 5 | Pages | 690-6 |
| PubMed ID | 27019013 | Mgi Jnum | J:234699 |
| Mgi Id | MGI:5790721 | Doi | 10.1038/nn.4280 |
| Citation | Cosker KE, et al. (2016) The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability. Nat Neurosci 19(5):690-6 |
| abstractText | To achieve accurate spatiotemporal patterns of gene expression, RNA-binding proteins (RBPs) guide nuclear processing, intracellular trafficking and local translation of target mRNAs. In neurons, RBPs direct transport of target mRNAs to sites of translation in remote axons and dendrites. However, it is not known whether an individual RBP coordinately regulates multiple mRNAs within these morphologically complex cells. Here we identify SFPQ (splicing factor, poly-glutamine rich) as an RBP that binds and regulates multiple mRNAs in dorsal root ganglion sensory neurons and thereby promotes neurotrophin-dependent axonal viability. SFPQ acts in nuclei, cytoplasm and axons to regulate functionally related mRNAs essential for axon survival. Notably, SFPQ is required for coassembly of LaminB2 (Lmnb2) and Bclw (Bcl2l2) mRNAs in RNA granules and for axonal trafficking of these mRNAs. Together these data demonstrate that SFPQ orchestrates spatial gene expression of a newly identified RNA regulon essential for axonal viability. |
