| Primary Identifier | IPR015253 | Type | Domain |
| Short Name | CST_STN1_C |
| description | Stn1 is a component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites [, ]. This entry represents the C-terminal domain of Stn1, which has two winged helix-turn-helix (wHTH) motifs, wHTH1 and wHTH2 [, ]. wHTH1 is structurally similar to that in RPA32 with an additional large insertion between helices alpha2 and alpha3, unique to Stn1, and it may allow interaction with a different set of proteins that function at telomeres such as Ctc1 []. wHTH2 is most similar to the DNA-binding wHTH motifs of the pur operon repressor and RepE replication initiator, but it does not bind double-stranded DNA []. |
