| Primary Identifier | MGI:5705326 | Allele Type | Targeted |
| Gene | Alk | Transmission | Germline |
| Strain of Origin | 129S2/SvPas | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Exon 23 was replaced with one in which a point mutation (TTC to CTC) that results in the amino acid substitution of leucine for phenyalanine at position 1178. This mutation corresponds to the F1174 identified in patients with neuroblastoma. Cre-mediated recombination removed the neomycin resistance cassette inserted downstream of the modified exon. |
