| First Author | Hansford LM | Year | 2003 |
| Journal | Cytogenet Genome Res | Volume | 101 |
| Issue | 1 | Pages | 17-23 |
| PubMed ID | 14571131 | Mgi Jnum | J:86353 |
| Mgi Id | MGI:2679474 | Doi | 10.1159/000073412 |
| Citation | Hansford LM, et al. (2003) Cloning and characterization of the human neural cell adhesion molecule, CNTN4 (alias BIG-2). Cytogenet Genome Res 101(1):17-23 |
| abstractText | We report the isolation and characterization of human contactin 4 (CNTN4), a brain-derived, immunoglobulin superfamily molecule-2 (alias BIG-2) as a candidate gene responsible for the differentiation potential of human neuroblastoma cells. Northern blot analysis showed highest CNTN4 expression in testes, thyroid, small intestine, uterus and brain. Induction of CNTN4 mRNA expression in human neuroblastoma tumor cells treated with retinoic acid correlated with a block in retinoid-induced neuritogenesis. Our findings suggest a role for human contactin 4 protein in the response of neuroblastoma cells to differentiating agents. |
