| First Author | Dickie MM | Year | 1969 |
| Journal | Mouse News Lett | Volume | 41 |
| Pages | 30-1 | Mgi Jnum | J:30724 |
| Mgi Id | MGI:78287 | Citation | Dickie MM (1969) New Mutants: chs-1, Op, lm, sh-1r, Asy, td. Mouse News Lett 41:30-1 |
| abstractText | Full text of MNL contribution: M.M. Dickie. New Mutants: 3. A dominant mutation, called lethal milk, symbol Lm, arose in strain C57BL/6J in 1964. This mutation causes the females to produce milk that is lethal to the offspring at 5 to 8 days of age. The offspring appear to swell, and then to shrivel and dry up, joints stiffen, mouths remain open, and death ensues around 6 to 8 days of age. If 5-day old offspring are fostered on normal females they do not survive; however, if offspring are fostered at 0 to 2 days of age most survive, mature and can reproduce. If normal 5- or 7-day old litters are fostered on lethal milk females, most of these animals survive but tend to be runty at weaning. If, however, newborn normal mice are fostered on lethal milk females, they die at 6 to 8 days of age. If three successive newborn normal litters are fostered on an Lm female at 5 day intervals, these three litters all die at 6 to 8 days of age. Attempts to feed the offspring, supplemental feeding of the females, and pituitary implants failed to improve survival of the offspring. Tests of the female offspring of outcrossed males of the lethal milk stock have shown that the condition is also transmitted through the males. Certain biochemical tests have been. made by Drs. Coleman, Kandutsch, and Meier. The fat components appear to.be normal, total fat is 42.7% (normal for C57BL/6J is 42.5 %) both normal and lethal milk have 21 fatty acids, the vitamin A and D content of liver of normal and dying young is normal. The protein components also appear to be normal. |
