| First Author | Leyns L | Year | 1997 |
| Journal | Cell | Volume | 88 |
| Issue | 6 | Pages | 747-56 |
| PubMed ID | 9118218 | Mgi Jnum | J:40838 |
| Mgi Id | MGI:892576 | Doi | 10.1016/s0092-8674(00)81921-2 |
| Citation | Leyns L, et al. (1997) Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Cell 88(6):747-56 |
| abstractText | Frzb-1 is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. Frzb-1 is widely expressed in adult mammalian tissues. In the Xenopus gastrula, it is expressed and regulated as a typical Spemann organizer component. Injection of frzb-1 mRNA blocks expression of XMyoD mRNA and leads to embryos with enlarged heads and shortened trunks. Frzb-1 antagonizes the effects of Xwnt-8 ectopic expression in a non-cell-autonomous manner. Cultured cells transfected with a membrane-tethered form of Wnt-1 bind epitope-tagged Frzb-1 in the 10(-10) M range. The results strengthen the view that the Spemann organizer is a source of secreted inhibitory factors. |
