| First Author | Nakatsuru Y | Year | 1989 |
| Journal | Mutat Res | Volume | 219 |
| Issue | 1 | Pages | 51-6 |
| PubMed ID | 2911271 | Mgi Jnum | J:25993 |
| Mgi Id | MGI:73834 | Doi | 10.1016/0921-8734(89)90040-4 |
| Citation | Nakatsuru Y, et al. (1989) Age and strain dependence of O6-methylguanine DNA methyltransferase activity in mice. Mutat Res 219(1):51-6 |
| abstractText | The activity of the DNA repair protein O6-methylguanine DNA methyltransferase (MT) was compared in liver extracts from female ICR and male C57BL/6 mice at various ages (3-130 weeks old). Similar patterns of overall enzyme activity were observed in both strains with O6-MT activity being relatively low in young mice (3 or 8 weeks old). However, the activity significantly increased after adolescence (middle age), thereafter decreasing with old age (over 100 weeks old) to a level equivalent to that found in young mice. In an additional strain difference study, O6-MT activities in liver extracts from 4 strains of mice were compared at 5 and 30 weeks of age. Although a similar age-associated increase of enzyme activity in adolescence was confirmed in all 4 strains investigated, the closed-colony ICR mice differed from the inbred strains in demonstrating significantly higher levels of O6-MT activity in females than in males. However, the same tendency was also observed in a comparison of the sexes in 30-week-old C3H/HeN, C57BL/6 and BALB/c mice. |
