| Primary Identifier | IPR044093 | Type | Domain |
| Short Name | STKc_CDK10 |
| description | Cyclin-dependent kinases (cdks) are the catalytic subunits of a large family of serine/threonine protein kinases (STKs). They are key regulators of eukaryotic cell cycle progression. CDK10 (also known as PISSLRE) is a cdc2-related kinase that contains the canonical regulatory Tyr and Thr residues present in all protein kinases and a PSTAIRE-like motif named PISSLRE []. CDK10 is essential for cell growth and proliferation, and acts through the G2/M phase of the cell cycle []. CDK10 has also been identified as an important factor in endocrine therapy resistance in breast cancer. CDK10 silencing increases the transcription of c-RAF and the activation of the p42/p44 MAPK pathway, which leads to antiestrogen resistance. Patients who express low levels of CDK10 relapse early on tamoxifen []. |
