Primary Identifier | MGI:1859871 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Tnfrsf4 |
Transmission | Germline | Strain of Origin | 129S4/SvJae |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A neomycin cassette was used to replace four exons, which code for the first 143 amino acids of the protein. Activated T cells from homozygous mutant animals lacked expression of Tnfrsf4 as detected by flow cytometry with the OX86 mAb as well as a soluable ligand fusion protein. |