| First Author | Tsai HC | Year | 2009 |
| Journal | Science | Volume | 324 |
| Issue | 5930 | Pages | 1080-4 |
| PubMed ID | 19389999 | Mgi Jnum | J:149736 |
| Mgi Id | MGI:3849066 | Doi | 10.1126/science.1168878 |
| Citation | Tsai HC, et al. (2009) Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Science 324(5930):1080-4 |
| abstractText | Natural rewards and drugs of abuse can alter dopamine signaling, and ventral tegmental area (VTA) dopaminergic neurons are known to fire action potentials tonically or phasically under different behavioral conditions. However, without technology to control specific neurons with appropriate temporal precision in freely behaving mammals, the causal role of these action potential patterns in driving behavioral changes has been unclear. We used optogenetic tools to selectively stimulate VTA dopaminergic neuron action potential firing in freely behaving mammals. We found that phasic activation of these neurons was sufficient to drive behavioral conditioning and elicited dopamine transients with magnitudes not achieved by longer, lower-frequency spiking. These results demonstrate that phasic dopaminergic activity is sufficient to mediate mammalian behavioral conditioning. |
