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Protein Coding Gene : Frs2 fibroblast growth factor receptor substrate 2

Primary Identifier  MGI:1100860 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  327826
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables transmembrane receptor protein tyrosine kinase adaptor activity. Acts upstream of or within several processes, including camera-type eye development; nervous system development; and regulation of MAPK cascade. Located in cell-cell junction; cytoplasm; and plasma membrane. Is expressed in several structures, including blastocyst; central nervous system; genitourinary system; gut; and immune system. Orthologous to human FRS2 (fibroblast growth factor receptor substrate 2).
PHENOTYPE: Homozygous null mice exhibit embryonic lethality between E5.75 and E8 and defects in primitive streak formation and anterior-posterior axis formation. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA C330018A15 gene,
  • SNT1,
  • Frs2alpha,
  • C330018A15Rik,
  • fibroblast growth factor receptor substrate 2,
  • MGI:2442871,
  • Frs2

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

53 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For