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Protein Coding Gene : Phlpp1 PH domain and leucine rich repeat protein phosphatase 1
Primary Identifier  MGI:2138327 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  98432
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable protein serine/threonine phosphatase activity. Involved in regulation of T cell anergy. Acts upstream of or within entrainment of circadian clock. Predicted to be located in nuclear membrane; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in ventricular layer. Orthologous to human PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1).
PHENOTYPE: Mice homozygous for a null mutation display impairment in the ability to stabilize the circadian period after light induced resetting. [provided by MGI curators]
  • synonyms:
  • PH domain and leucine rich repeat protein phosphatase,
  • Phlpp1,
  • pleckstrin homology domain containing, family E (with leucine rich repeats) member 1,
  • Plekhe1,
  • Phlpp,
  • expressed sequence AI836256,
  • mKIAA0606,
  • PH domain and leucine rich repeat protein phosphatase 1,
  • AI836256
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

3 Involved In Mutations

Trail: ProteinCodingGene

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

4 Pathways

Trail: ProteinCodingGene

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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