| First Author | Tsitsikov EN | Year | 1994 |
| Journal | Mol Immunol | Volume | 31 |
| Issue | 12 | Pages | 895-900 |
| PubMed ID | 7520529 | Mgi Jnum | J:19991 |
| Mgi Id | MGI:68107 | Doi | 10.1016/0161-5890(94)90009-4 |
| Citation | Tsitsikov EN, et al. (1994) Structure of the murine CD40 ligand gene. Mol Immunol 31(12):895-900 |
| abstractText | The mouse CD40 ligand (CD40L) gene was cloned, sequenced and characterized. DNA sequence analysis showed that the CD40L gene comprises five exons and four intervening introns, spread over 13-14 kb of genomic DNA. The putative site for initiation of mRNA transcription was identified at 67 bp upstream of the translation initiation (ATG) codon. The nucleotide sequence of the 5'-flanking region of this gene revealed the presence of several regulatory regions including a TATA-like box, an Sp1-like box and six potential NF-AT-like motifs. The 3'-untranslated region of the murine CD40L gene contained two ATTTA-elements which are thought to confer instability to the mRNA of many cytokines and two adjacent dinucleotide repeates, (CT)25 and (CA)45. These elements may play a role in the post-transcriptional regulation of CD40L gene expression. |
