| First Author | Rantakokko J | Year | 1999 |
| Journal | Matrix Biol | Volume | 18 |
| Issue | 2 | Pages | 155-61 |
| PubMed ID | 10372556 | Mgi Jnum | J:55345 |
| Mgi Id | MGI:1337737 | Doi | 10.1016/s0945-053x(99)00010-4 |
| Citation | Rantakokko J, et al. (1999) Complete genomic structure of the mouse cathepsin K gene (Ctsk) and its localization next to the Arnt gene on mouse chromosome 3. Matrix Biol 18(2):155-61 |
| abstractText | In preparation for gene manipulative experiments in mice we have isolated genomic clones covering the entire murine cathepsin K gene (Ctsk). Sequence analysis revealed that the gene spans 10.1 kb and contains eight exons and seven introns. The sizes of the coding exons 2-7 as well as the pattern of intron sizes are conserved between the human and mouse cathepsin K genes. Genomic organization of the mouse cathepsin K gene also closely resembles those of cathepsins S and L. More than 26% of the Ctsk sequence consists of different repetitive elements. Detailed sequence analysis of 1.7 kb of Ctsk promoter revealed several putative binding sites for transcription factors and two stretches of 280-320 bp which were >70% homologous with the human cathepsin K promoter. Analysis of genomic clones extending further upstream of the Ctsk gene identified the 3' end of the gene coding for arylhydrocarbon-receptor nuclear translocator (Amt). This places Ctsk approximately 4.5 kb downstream of Amt on mouse chromosome 3 at locus 47.9. (C) 1999 Elsevier Science B.V./International Society of Matrix Biology. All rights reserved. |
