| First Author | Muzaki ARBM | Year | 2017 |
| Journal | J Immunol | Volume | 199 |
| Issue | 10 | Pages | 3691-3699 |
| PubMed ID | 29030488 | Mgi Jnum | J:255697 |
| Mgi Id | MGI:6105160 | Doi | 10.4049/jimmunol.1701053 |
| Citation | Muzaki ARBM, et al. (2017) Long-Lived Innate IL-17-Producing gamma/delta T Cells Modulate Antimicrobial Epithelial Host Defense in the Colon. J Immunol 199(10):3691-3699 |
| abstractText | Intestinal IL-17-producing cells, including Th17, gamma/delta T, and innate lymphoid cells, are differentially distributed along the gastrointestinal tract. In this study, we show that the gut IL-17-producing gamma/delta T (gamma/delta T17) cells develop before birth and persist in the tissue as long-lived cells with minimal turnover. Most colon gamma/delta T17 cells express, together with Vgamma4 and CCR6, the scavenger receptor 2 and are mainly restricted to innate lymphoid follicles in the colon. Colon gamma/delta T cells in mice that lack conventional dendritic cells 2 produced increased amounts of IL-17 with concomitant heightened epithelial antimicrobial response, such as the C-type lectins Reg3gamma and Reg3beta. In the absence of gamma/delta T cells or after IL-17 neutralization, this epithelial response was dramatically reduced, underlining the protective role of this unique subpopulation of innate gamma/delta T17 cells in the colonic mucosa. |
